Guide to play the board game Guess Who. Category. Education. License. Standard YouTube License. Show. Guess Who Game Rules: How Do You Play Guess Who? Game Overview: Guess Who is a two player game where players use differential yes or no questions to. OBJECT. Guess your opponent's Mystery. Person before your opponent guesses yours. CONTENTS. 2 Plastic Gameboards, 48 Plastic. Frames, 48 Face Cards.